PENEGRA is indicated for the treatment of Erectile Dysfunction. PENEGRA helps in the relaxation of the blood vessels of the penis. The physiologic mechanism of erection of the penis involves release of Nitric Oxide in the corpus cavernosum during sexual stimulation. Nitric Oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and the blood vessels of the penis. PENEGRA has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of Nitric Oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.

PENEGRA is indicated for the treatment of Erectile Dysfunction. PENEGRA helps in the relaxation of the blood vessels of the penis. The physiologic mechanism of erection of the penis involves release of Nitric Oxide in the corpus cavernosum during sexual stimulation. Nitric Oxide then activates the enzyme guanylate cyclase, which results in increased levels of cyclic guanosine monophosphate (cGMP), producing smooth muscle relaxation in the corpus cavernosum and the blood vessels of the penis. PENEGRA has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of Nitric Oxide by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum.